Scale-up
What does "scale-up" mean?
Why is scaling up important?
Test laboratory
At Three-Tec’s testing and application lab, existing and new processes can be developed and optimized under realistic conditions before being transferred to production. Learn more on our page about the Test laboratory or in the article Tests with your original products in our laboratory.
Frequently Asked Questions
What steps are involved in a typical scale-up process?
A successful scale-up typically involves six steps: a laboratory feasibility study, formulation development and optimization, definition of critical process parameters, testing on pilot plants, transfer to production facilities, and final process validation.
Which process parameters are particularly critical during scale-up?
The most important factors include residence time, shear rate, temperature profile, material throughput, mixing intensity, and dosing accuracy. Even small deviations in these parameters can affect product quality. Only documented processes can be reliably replicated.
Why is precise dosing important for a successful scale-up?
A stable and consistent supply of raw materials is essential for reliably transferring process results from the laboratory to larger-scale facilities.
Why do modular systems make scale-up easier?
If laboratory equipment and production facilities have similar screw geometries and comparable process conditions, a process developed in the laboratory can be transferred to production much more easily and reliably.